The first study to show that obesity can accelerate the directly
progression of acute lymphoblastic leukemia (ALL) is carried out on
The Saban Research Institute for Childrens Hospital Los Angeles and was
Cancer Prevention Research, published on 5 October 2010. obesity
associated with an increased incidence of many types of cancer, including
leukemia, but it is unknown whether was the increase in the number of cases
a direct effect of obesity or in connection with genetic, lifestyle,
health, or socio-economic factors.
Appear in bold in red, structural cells are displayed in blue and leukaemia cells displayed in a yellow (photo: Business Wire)
"Given the high prevalence of obesity in our society, we felt it was
critical to determine if the increase in overweight causes
of leukaemia and no other associated exposure, "says Steven d.
Mittelman, MD, PhD, a paediatric endocrinologist who led the study.
Dr. Mittelman and his colleagues a high-fat diet used for the generation of obesity
in two mouse models for all. Mice were randomised to a high-fat or a
control diet. the researchers found that obesity increases the risk of
ALL in both models, especially in older mice. This comment was
According to the type of a cumulative effect with other
exposure related cancers, such as lung cancer with regard to smoking and
As a result of breast cancer increased estrogen exposure. compliance with the
difference in older animals also agreed with the other obesity
effects of cumulative exposure such as heart disease, diabetes, and
arthritis.
"Our results are consistent with the epidemiological data which show that a
higher incidence of leukemia in obese adults and proposes that this
comments are actually due to obesity, and some do not connected
genetic, socio-economic, or lifestyle factor, "Dr Mittelman, closed
who is also an Assistant Professor of Paediatrics and Physiology &
Biophysics at the Keck School of Medicine of the University of Southern
California. "This information mean that certain hormones or factor in obesity
individuals, maybe produced by fat tissue itself, the signal of leukemia
cells to grow and divide. leukemia is the most common type of
cancer, obesity can understand how increasing the frequency
could have significant public health consequences. "
Co-authors of the study included Jason P. Yun, James w. Behan, Nora
Hei, PhD, Anna Butturini, MD, Lars Groffen Klemm, John, PhD,
Lingyun-Ji and Markus Muschen, MD, PhD, of Childrens Hospital Los
Angeles.
The study was funded by the National Institute of the child
Health and human development, the National Cancer Institute, and the
Children's Cancer Research Fund (a non-profit organization for California).
The Saban Research Institute for Childrens Hospital Los Angeles is one of
the largest and most productive pediatric research facilities in the
100 researchers in 186 laboratory, United States of America
clinical trials as well as community-based research and The health services.
Saban Research Institute is eighth ranked in the National Institutes of
Health financing among children of hospitals in the United States.
Founded in 1901, Childrens Hospital Los Angeles is one of the nation
children's hospitals and is recognized worldwide for his
leading role in the health of children and adolescents. Childrens Hospital Los
Angeles is one of only seven children of hospitals in the country and
the only children's Hospital on the West Coast-sized for two
consecutive years in each of the 10 pediatric specialties in the u.s. news &
World report rankings and the name of the magazine "Honor Roll" of
children's hospitals.
Childrens Hospital Los Angeles is a premier academic hospital and has
connected to the Keck School of Medicine of the University of
Southern California since 1932.
Photos/multimedia gallery available: http://www.businesswire.com/cgi-bin/mmg.cgi?eid=6461226&lang=en
Childrens Hospital Los Angeles
Ellin Kavanagh, 323-428-8336
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